UW CYTOGENETIC SERVICES

 

 

Cytogenetics involves the study of human chromosomes in health and disease. Chromosome studies are an important laboratory diagnostic procedure in prenatal diagnosis, in certain patients with mental retardation and multiple birth defects, in patients with abnormal sexual development, and in some cases of infertility or multiple miscarriages. Cytogenetic analysis is also useful in the study and treatment of patients with malignancies and hematologic disorders. New techniques allow for increased resolution of chromosome banding patterns, permitting differentiation of a greater number of abnormalities.

In July, 2002, Waisman Center Cytogenetics and WSLH Cytogenetics merged to form UW Cytogenetic Services (UWCS).  The UWCS laboratory is certified by CLIA (Clinical Laboratory Improvement Act), CAP (College of American Pathologists), and is COG (Childhood Oncology Group) approved.  We provide chromosome analysis on a variety of specimens, including amniotic fluid, chorionic villus samples, tissue biopsies, products of conception, peripheral blood, bone marrow, lymph nodes, solid tumors, and pleural effusions.  Cytogenetic studies are performed for prenatal diagnosis, to investigate infertility, to aid in identifying the cause of spontaneous abortions, to aid in determining the etiology of congenital anomalies, mental retardation, and learning disabilities, and to identify acquired chromosome abnormalities associated with neoplasia.

 

 

News From UW Cytogenetic Services

List of Available Tests

DNA Banking Brochure and DNA Banking Forms

UW Receives Accreditation for Molecular Genetics Fellowship

UW Cytogenetics Participates in UW Cancer Research

Webcast: Genetics Testing Services

Webcast: Detecting Genomic Imbalances in Stillborn Infants

 


Chromosomal Abnormalities in Cancer- a listing of neoplastic disorders including examples of associated chromosomal abnormalities



Related Sites - database searches, support/information on specific disorders, training in cytogenetics and genetic counseling



Case Conference- a presentation of a recent interesting case, with the opportunity to analyze a metaphase spread before viewing the karyotype, description and discussion. (Replaces "Case of the Month"- no further updates)

  


 
Abnormalities that can be detected by cytogenetics: Some of the procedures that we perform:
  • Translocations
  • Deletions
  • Inversions
  • Numerical aberrations

 Tests available: (link to search form)

Cytogenetics Tests Brochure

- enter test (i.e. cytogenetic, FISH, PCR, etc
  • Amniotic fluid
  • Blood
    • High resolution
    • Unstimulated for hematalogic disorders
    • Percutaneous umbilical
  • Bone marrow
  • Chorionic villus sampling
  • Tissue
    • chromosome analysis
    • culture only
  • Fluorescent in-situ hybridization (FISH)
  • Solid tumor/lymph node
  • DNA Banking
  • Methylation-Sensitive PCR for Prader-Willi/Angelman syndrome detection
  • RT-PCR (qualitative and quantitative)
  • JAK-2 analysis
  • Fragile-X syndrome analysis

 Specimen Sending Instructions

 Neoplastic Diagnosis Request Form

 Genetic Diagnosis Request Form

 DNA Banking Forms

 Request Forms can be ordered by calling the Clinical Orders Department at (800) 862-1088 or (608) 265-2966. 


Address:
UW Cytogenetic Services
465 Henry Mall, Room 419
Madison, WI 53706

 

Email: cytogenetics@mail.slh.wisc.edu
Send us your comments, questions and suggestions.
Telephone: (608) 262-0402 FAX: (608) 265-7818


Questions about a specific disorder? training? -check out the Links to other sites also.

Site maintained by Eric B. Johnson ebjohnso@wisc.edu